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pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can minimize panobinostat amounts by ~70% and cause remedy failure.pentobarbital will lessen the level or outcome of carvedilol by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.bupreno